Analgesic and anti-inflammatory properties of bipharmacophore prodrug derivatives based on pyridoxine and ketorolac

The analgesic and anti-inflammatory properties of trisand tetrakis-derivatives of pyridoxine and ketorolac were examined using mechanical and chemical irritation tests and acute inflammation model. In the carrageenan-induced paw edema, acetic acid-induced writhing, and cute exudative inflammation models, the compounds provided analgesic efficacy comparable to that of ketorolac tromethamine, the most potent non-opioid analgesic, but with a longer duration of action and reduced toxicity after 14 days of daily intragastric administration.