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October 15, 2025Iranian Journal of MicrobiologyOpen Access

Phylogenetic analysis of bla NDM genes of carbapenem resistant uropathogens isolated from federal tertiary care hospital, Pakistan: insights into the evolution and dissemination of drug resistance

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Authors

MSMuhammad ShafiqAKAhmad KhanMHMuhammad Zeeshan Hyder

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Overview

This research investigates carbapenem-resistant Enterobacterales in uropathogens, showing higher bla NDM prevalence and antibiotic resistance levels.

Key Points

  • The study shows that 11.92% of Enterobacterales were carbapenem resistant, raising concerns about public health.
  • Among CRE isolates, 45% were positive for the bla NDM gene, predominantly found in Klebsiella pneumoniae.
  • Phylogenetic analysis indicated diverse relationships of bla NDM variants with sequences from Pakistan and globally.
  • The findings highlight the urgent need for monitoring and antibiotic stewardship due to rising carbapenem resistance.

Cite This Study

Shafiq et al. (2025) studied this question.

synapsesocial.com/papers/68ef858cc6a308ba0635563dhttps://doi.org/10.18502/ijm.v17i5.19883
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NDM Production as a Dominant Feature in Carbapenem-Resistant Enterobacteriaceae Isolates from a Tertiary Care Hospital2021 · 21 citations
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  3. 3Genomic characterization of plasmids harboring bla<sub>NDM-1,-5,-7</sub>carbapenemase alleles in clinical Klebsiella pneumoniae in Pakistan2024 · 1 citations
  4. 4Global geographic and genomic epidemiology analysis of carbapenem-resistant <i>Escherichia coli</i> carrying <i>bla</i> <sub>NDM-9</sub>2025 · 2 citations
  5. 5Global geographic and genomic epidemiology analysis of carbapenem-resistant <i>Escherichia coli</i> carrying <i>bla</i> <sub>NDM-9</sub>2025