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October 11, 2025BMC Infectious DiseasesOpen Access

Molecular characterization of blaNDM and other carbapenemases genes among carbapenem-resistant Enterobacterales from community-and hospital- acquired urinary tract infections

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Authors

LRLubna RazaqFUFakhur UddinWAWissal Audah Alhilfi

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Overview

Analysis identifies high prevalence of carbapenem-resistant Enterobacterales in hospital-acquired infections, suggesting urgent action is needed.

Key Points

  • In hospital-acquired (HA) urinary tract infections, carbapenem resistance was significantly higher at 60.8%, compared to 6.5% in community-acquired (CA) cases.
  • The blaNDM gene was detected in 86.5% of carbapenem-resistant Enterobacterales (CRE), indicating a significant threat in treatment options.
  • Among 181 isolates, E. coli was the prevalent uropathogen at 70.7%, highlighting the need for targeted intervention strategies.
  • Chi-square analysis demonstrated significantly greater antimicrobial resistance in HA-UTI isolates compared to CA-UTI, stressing the need for awareness.

Cite This Study

Razaq et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558ced1ahttps://doi.org/10.1186/s12879-025-11548-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypic versus molecular assays for detecting carbapenemase-producing Enterobacterales from urinary tract infections2024 · 1 citations
  2. 2Phenotypic and Genotypic Detection of Carbapenem Resistance in Urinary Enterobacterales Isolates: A Prospective Cross-Sectional Diagnostic Evaluation Study2026
  3. 3NDM Production as a Dominant Feature in Carbapenem-Resistant Enterobacteriaceae Isolates from a Tertiary Care Hospital2021 · 21 citations
  4. 4Phylogenetic analysis of bla NDM genes of carbapenem resistant uropathogens isolated from federal tertiary care hospital, Pakistan: insights into the evolution and dissemination of drug resistance2025
  5. 5Common Genotypes of Carbapenamase Observed in Members of the Enterobacteriaceae in Tertiary Care Hospital in South India2025 · 1 citations