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October 15, 2025Journal of Applied Pharmaceutical ScienceOpen Access

Red rice bran extract attenuates oxidative stress and testicular damage in high-fat diet/streptozotocin-induced diabetic rats

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Authors

WJWatcharaporn Preedapirom JeefooUniversity of PhayaoAOAtcharaporn OntawongUniversity of PhayaoSPSirinat PengnetUniversity of Phayao

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Overview

Observational analysis shows red rice bran extract alleviates oxidative stress and enhances sperm quality in type 2 diabetes rats, suggesting potential for reproductive health.

Key Points

  • Treatment with red rice bran extract significantly improved sperm concentration and Johnsen score in diabetic rats.
  • Diabetic rats exhibited elevated oxidative stress and reduced testosterone levels compared to control, with oxidative damage markers being assessed.
  • The study involved male Wistar rats induced with diabetes through a high-fat diet and low-dose streptozotocin injections.
  • These findings highlight the potential of red rice bran extract as a natural therapy for diabetes-related reproductive issues.

Cite This Study

Jeefoo et al. (2025) studied this question.

synapsesocial.com/papers/68efa18f9d05deea71d13f43https://doi.org/10.7324/japs.2026.249609
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Also Consider

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  1. 1Retama raetam Extract for Testicular Health in Type 2 Diabetic Rats: Insight View on the Steroidogenesis, Antioxidants, and Molecular Docking Scores of Bioactive Compounds against Bax2024 · 1 citations
  2. 2Red Rice Bran Extract Alleviates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease and Dyslipidemia in Mice2023 · 24 citations
  3. 3Rosemary leaf extract alleviates testicular impairment, oxidative stress, and apoptosis in streptozotocin-induced diabetic rats2024
  4. 4Tirzepatide ameliorates type 2 diabetes–associated male reproductive dysfunction via modulation of the Nrf2/Keap1 pathway2026 · 1 citations
  5. 5Therapeutic Potential of <i>Cynara scolymus</i> Extract and <i>Bifidobacterium longum</i> in Alleviating Diabetes‐Induced Male Reproductive Dysfunction2025