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October 15, 2025Open Access

Joint multi-omics profiling of brain and body health in aging

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Authors

AFAsa FarahaniZLZhen-Qi LiuFMFilip Morys

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Overview

Analysis reveals aging impacts brain health alongside peripheral biomarkers, suggesting metabolic health is vital.

Key Points

  • Brain health deteriorates with aging, involving loss of structural integrity and vascular dysfunction.
  • Findings indicate that low HDL cholesterol and elevated BMI are linked to cognitive deficits in aging populations.
  • Partial least squares analysis reveals two major brain-body health axes associated with age and metabolic features.
  • Study emphasizes the need for integrated biomarkers to assess brain health in relation to systemic bodily health.

Cite This Study

Farahani et al. (2025) studied this question.

synapsesocial.com/papers/68eff7392ae617e5891a93e3https://doi.org/10.1101/2025.10.09.681483
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