Design, Synthesis, and Biological Evaluation of Procaine-Based Triazole-Isoxazoline Hybrids as Selective PI3K/mTOR Inhibitors for Esophageal Cancer Therapy: An in-vitro, and in-vivo study

Q: What type of study is this?

This is a In Vitro Study study (also classified as: Animal Study).

Yinliang Sheng; Bing Wu; Feng Li; Chunyang Zhang

doi:10.1039/d5md00554j

January 1, 2025RSC Medicinal Chemistry

Design, Synthesis, and Biological Evaluation of Procaine-Based Triazole-Isoxazoline Hybrids as Selective PI3K/mTOR Inhibitors for Esophageal Cancer Therapy: An in-vitro, and in-vivo study

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Key Points

Chemical compounds created from procaine show enhanced activity against esophageal cancer cells compared to traditional treatments.
The study highlights the selective inhibition of PI3K/mTOR pathways with these hybrids, which are key in cancer growth.
In-vitro tests indicated significant anticancer effects, while in-vivo results further validated the efficacy of these new compounds.
This research indicates that procaine-based hybrids may pave the way for new treatment options in esophageal cancer therapy.

Implication

In-vitro and in-vivo evaluation highlights procaine derivatives' effectiveness against esophageal cancer, suggesting potential as targeted therapy.

Abstract

A novel series of procaine derivatives incorporating 1,2,3-triazole and isoxazoline scaffolds was developed and evaluated for their anticancer potential, particularly against esophageal cancer. Initially, the synthesized compounds were screened for...

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Cite This Study

Sheng et al. (2025) studied this question.

synapsesocial.com/papers/68f04acce559138a1a06e838 https://doi.org/10.1039/d5md00554j

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Design, Synthesis, and Biological Evaluation of Procaine-Based Triazole-Isoxazoline Hybrids as Selective PI3K/mTOR Inhibitors for Esophageal Cancer Therapy: An in-vitro, and in-vivo study

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, Synthesis, and Biological Evaluation of Procaine-Based Triazole-Isoxazoline Hybrids as Selective PI3K/mTOR Inhibitors for Esophageal Cancer Therapy: An in-vitro, and in-vivo study

Key Points

Implication

Abstract

Discussion

Cite This Study

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