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October 16, 2025Journal of Chemical Technology & BiotechnologyOpen Access

Sustainability impacts for converting to Raman spectroscopy inline monitoring from traditional offline manual sampling in small‐scale and large‐scale biomanufacturing

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Authors

SSS. SimonBabeș-Bolyai UniversityPPPhyllis C. PughAstraZeneca (Poland)PBPreeya K Boppana

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Overview

Analysis shows reducing carbon emissions and plastic waste in biomanufacturing with Raman spectroscopy adoption.

Key Points

  • Integrating Raman spectroscopy significantly decreases carbon emissions and single-use plastic waste during biomanufacturing.
  • Quantitative analysis reveals a reduction of 80.17 kg CO₂ emissions and 13.36 kg of plastic waste per production run.
  • Real-time monitoring using Raman technology maintains closed systems, thus reducing contamination risks and improving product integrity.
  • Adopting this technology supports industry-wide goals for sustainability and operational efficiency.

Cite This Study

Simon et al. (2025) studied this question.

synapsesocial.com/papers/68f0ba59c50c73ebef9faa6chttps://doi.org/10.1002/jctb.70084
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Also Consider

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  1. 1Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in‐line Raman spectroscopy probe2010 · 322 citations
  2. 2Monitoring a bioprocess for ethanol production using FT-MIR and FT-Raman spectroscopy2001 · 107 citations
  3. 3Raman Spectroscopy Cell-based Biosensors2007 · 352 citations