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This is a Experimental Study study.

Electroreductive Homo-coupling of Quinolines for the Regioselective Synthesis of 1,2,3,4-Tetrahydro-2,3′-biquinolines

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Electrochemical reductive homo-coupling achieves selective synthesis of biquinolines, suggesting efficient chemical pathways.

A regioselective synthesis method produced 1,2,3,4-tetrahydro-2,3′-biquinolines from quinolines efficiently, demonstrating the potential for sustainable chemistry.
Utilizing diethyl phosphite and water as hydrogen sources, the method enables broad functional group tolerance and mild reaction conditions.
Mechanistic studies reveal that the reaction occurs via enamine-iminium intermediates, ensuring regioselectivity during C2–C3 coupling.
The developed biquinoline products serve as versatile scaffolds for further functionalization and chemical diversity, emphasizing their synthetic applications.

Xia et al. (2025) studied this question.

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