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October 17, 2025MicroorganismsOpen Access

Sodium Butyrate Supplementation in Whole Milk Modulates the Gastrointestinal Microbiota Without Altering the Resistome and Virulome in Preweaned Calves

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Authors

LXLingxiao XingChinese Academy of Medical Sciences & Peking Union Medical CollegeSNSong NiuShanxi UniversityDWDonglin WuInner Mongolia Agricultural University

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Overview

Supplementing whole milk with sodium butyrate alters gastrointestinal microbiota in preweaned calves without affecting resistome and virulome.

Key Points

  • Sodium butyrate supplementation increases beneficial bacteria in the rumen, enhancing gastrointestinal health in preweaned calves.
  • Significant shifts in microbial composition were noted in ruminal digesta, favoring genera like Actinobacteria and Bifidobacterium (p < 0.05).
  • Metagenomic analysis revealed that sodium butyrate did not impact the resistome or virulome, maintaining microbial stability (p > 0.05).
  • Key differences in antibiotic resistance and virulence factors were observed between the rumen and cecum, highlighting regional diversity in microbial communities.

Cite This Study

Xing et al. (2025) studied this question.

synapsesocial.com/papers/68f199b7de32064e504dc618https://doi.org/10.3390/microorganisms13102375
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