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This is a Quantitative Study study.

A Multi-Omics Investigation to Decipher the Paradoxical Context Dependent Role of the PTPN1 Gene in Cancer Prognosis

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Gene expression shifts linked to cancer prognosis in various subtypes, suggesting PTPN1 as a potential biomarker.

PTPN1 shows context-dependent expression variations across cancer subtypes, impacting survival rates significantly.
In 27 cancer subtypes, PTPN1 upregulation correlates with reduced patient survival, indicating its role in prognosis.
Enrichment analyses revealed significant KEGG pathway associations linked to PTPN1, underscoring its therapeutic potential.
Drug sensitivity tests found a positive correlation between PTPN1 expression and response to cancer therapies, implying its utility.

Raval et al. (2025) studied this question.

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