What question did this study set out to answer?

To evaluate the role of PTPN11 protein expression levels in the prognosis of acute myelogenous leukemia.

December 8, 2025BloodOpen Access

High levels of PTPN11 protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia

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Authors

EMEunice MagalhãesIscte – Instituto Universitário de Lisboa BBBrandon D. BrownUniversity of California, Riverside

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Implication

Observational findings reveal high PTPN11 protein levels reduce survival rates in acute myelogenous leukemia, suggesting therapeutic targets may benefit more patients.

Key Points

To evaluate the role of PTPN11 protein expression levels in the prognosis of acute myelogenous leukemia.
Measured protein levels in 806 AML samples using Reverse Phase Protein Arrays.
Analyzed mutation status and treatment outcomes for 521 cases with varying PTPN11 expression levels.
Used Cox proportional hazards models to assess overall survival based on PTPN11 levels and mutation status.
High PTPN11 protein levels associated with adverse overall survival in both mutant and wild-type cases.
Patients with high expression levels had worse responses to VH therapy compared to chemotherapy.
Low PTPN11 mutant cases performed similarly to low wild-type cases when treated with chemotherapy.

Cite This Study

Magalhães et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3dd https://doi.org/10.1182/blood-2025-1700

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Implication

Observational findings reveal high PTPN11 protein levels reduce survival rates in acute myelogenous leukemia, suggesting therapeutic targets may benefit more patients.

High levels of PTPN11 protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

High levels of PTPN11 protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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