Supplementary Figure 4 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Mohamed A. Gouda; Filip Janků; Ying Yuan; Leylah Drusbosky; Alice P. Chen; Xiaofeng Zheng; Keyur P. Patel; Stanley R. Hamilton; Mark J. Routbort; James V. Tricoli; P. Mickey Williams; A. John Iafrate; Jeffrey Sklar; Brent Coffey; Richard F. Little; Carlos L. Arteaga; Peter J. O’Dwyer; Keith T. Flaherty; Lyndsay N. Harris; Funda Meric‐Bernstam

doi:10.1158/1078-0432.30363477

Key Points

Genomic alterations in patients were identified using plasma and tumor tissue samples, which adds to the understanding of mutation detection.
Patients receiving taselisib with PIK3CA mutations showed varying treatment responses, depicted by response stratification.
The analysis involved comparing the presence of mutations in both tissue and plasma, offering insights into the mutations’ distribution.
Findings highlight the importance of accurate mutation detection in guiding treatment decisions for patients involved in the trial.

Implication

Observational analysis confirms genomic alterations in tumor tissue and plasma DNA for patients with PIK3CA mutations, suggesting treatment implications.

Abstract

Supplementary Figure 4. Genomic alterations detected in patients treated in subprotocol I enrolling patients with PIK3CA mutations who received treatment with taselisib. Patients are stratified according to the best overall response. Triangles are used to depict the presence of mutation in tissue (lower triangle) and/or plasma (upper triangle).

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Cite This Study

Gouda et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb0b https://doi.org/10.1158/1078-0432.30363477

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Supplementary Figure 4 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 4 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Key Points

Implication

Abstract

Discussion

Cite This Study

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