Observational analysis reveals associations between tRNA-derived fragments, immune infiltration, and drug response in CRC, suggesting diagnostic potential.
Figure S2. Illustrative examples of immune infiltration and drug response association analyses. A, The number (left y axis) and proportion of tRFs (right y axis) correlated with T cell CD4+ memory resting (top) and T cell gamma delta (bottom) were estimated using the CIBERSORT algorithm. B, Significant tRF-drug response pairs identified in CRC. The top 20 drugs (x axis) significantly associated with tRFs (y axis) are shown in the plot. C, The correlation between tRF-25-0P58309NDJ expression and drug response data of Linsitinib in TCGA CRC tissues. P-values and correlation coefficients were calculated using Spearman’s correlation analyses.
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