Supplementary Figure S5 from Clonal Hematopoiesis and Inflammation Predict Hematologic Toxicity and Secondary Myeloid Malignancies after B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy

Zachary M. Avigan; Jerrel L. Catlett; Saoirse Bodnar; Darren Pan; Adolfo Aleman; Taotao Sheng; Erin Moshier; Adriana Rossi; Shambavi Richard; Gurbakhash Kaur; Joshua Richter; Larysa Sanchez; Cesar Rodriguez; Hearn Jay Cho; Shafinaz Hussein; Christian Salib; Lewis R. Silverman; Sundar Jagannath; Samir Parekh; Santiago Thibaud

doi:10.1158/1078-0432.30363139

Key Points

Clonal hematopoiesis may predict hematologic toxicity following CAR-T therapy.
Figure S5 illustrates time to MDS/AML diagnosis correlated with previous treatment lines.
Linear regression analysis outlines the prediction relationship between therapy history and outcomes.
Implications suggest monitoring clonal hematopoiesis could guide patient management strategies.

Implication

Observational analysis shows links between clonal hematopoiesis, hematologic toxicity, and secondary malignancies after CAR-T therapy.

Abstract

Figure S5. (A) Scatter plot of time to MDS/AML diagnosis after CAR-T versus prior lines of therapy, with best fitting line shown by linear regression.

Discussion

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Cite This Study

Avigan et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcd65 https://doi.org/10.1158/1078-0432.30363139

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Supplementary Figure S5 from Clonal Hematopoiesis and Inflammation Predict Hematologic Toxicity and Secondary Myeloid Malignancies after B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S5 from Clonal Hematopoiesis and Inflammation Predict Hematologic Toxicity and Secondary Myeloid Malignancies after B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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