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Observational analysis reveals platelet-monocyte aggregates in remodeled vessels, highlighting potential signaling roles.
Using lung immunohistochemistry and stereology, platelets were found to accumulate and co‐localize with leukocytes, particularly monocytes, within the mural and adventitial space of remodeled vessels of patients with pulmonary arterial hypertension. The presumed signaling between these cell types invites further studies into the role of platelet‐monocyte aggregates in pulmonary hypertension.
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Farrell et al. (2025) studied this question.
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