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October 18, 2025Pulmonary CirculationOpen Access

Prognostic Role of Platelets in Pulmonary Arterial Hypertension

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Authors

CFCaio Júlio César dos Santos FernandesINIlma Alves de Oliveira NascimentoTOTalita Lacerda de Oliveira

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Overview

Retrospective analysis shows platelet counts predict prognosis in pulmonary arterial hypertension patients, indicating their role as biomarkers.

Key Points

  • Lower platelet counts were observed in pulmonary arterial hypertension patients compared to controls, indicating a possible relationship with disease severity.
  • Mean platelet volume was significantly reduced in idiopathic pulmonary arterial hypertension versus normopressoric controls, suggesting altered platelet function.
  • Survival analysis indicated that patients with normal platelet counts had better outcomes than those with thrombocytopenia, reinforcing the prognostic value of platelets.
  • This exploratory study suggests that platelet indices may serve as potential biomarkers in pulmonary vascular disease, warranting further investigation.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/68f396388da44caaba02ca20https://doi.org/10.1002/pul2.70180
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Also Consider

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  1. 1Platelet Activation Markers in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease2022 · 16 citations
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  5. 5Beyond Thrombosis: the Role of Platelets in Pulmonary Hypertension2020 · 47 citations