Why the study?
Is there evidence of ongoing platelet-fibrin thrombosis (elevated PF4, BTG, FPA, FPBB1-42) in patients with primary pulmonary hypertension compared to normal subjects?
Population
26 subjects: 10 patients with primary pulmonary hypertension, 9 normal volunteers, and 7 patients with…
Comparison
Measurement of peripheral venous blood markers… vs Normal volunteers and patients with secondary…
Design
Case-control
Key result
Patients with established primary or secondary pulmonary hypertension did not exhibit abnormal levels of platelet activation or fibrin formation markers compared to normal subjects.
Authors
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Does not support coagulation marker monitoring in established pulmonary hypertension; leaves open roles in early disease or thrombosis risk.
Cross-Sectional (n=26)
Is there evidence of ongoing platelet-fibrin thrombosis (elevated PF4, BTG, FPA, FPBB1-42) in patients with primary pulmonary hypertension compared to normal subjects?
The study suggests that a sustained state of abnormal platelet activation and fibrin formation or dissolution is not present in established pulmonary hypertension.
Schulman et al. (1993) conducted a cross-sectional in Pulmonary hypertension (n=26). Pulmonary hypertension vs. Normal volunteers was evaluated on Levels of platelet activation (PF4, BTG) and fibrin formation/dissolution (FPA, FPBB1-42) markers. Patients with established primary or secondary pulmonary hypertension did not exhibit abnormal levels of platelet activation or fibrin formation markers compared to normal subjects.
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