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February 28, 2025American Journal of Respiratory Cell and Molecular Biology

Pharmacological targeting of ICAM-1 mitigated pulmonary hypertension in a hypoxic murine model, an effect not observed in thrombocytopenic mice, demonstrating that GPIIb/IIIa-ICAM-1-mediated platelet-endothelial adhesion exacerbates pulmonary vascular thickening.

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Why the study?

Patients with pulmonary hypertension typically present with a diminished platelet count, but the role of platelets in PH development and progression remains unclear.

Population

Animal models of PH and patients with PH

Comparison

Platelet depletion, healthy vs PH platelet transfusion, and pharmacological targeting of ICAM-1

Design

Preclinical animal and translational mechanistic study

Authors

LCLingdan ChenQBQianwen BaiRTRuidi Tang

Discussion

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Overview

ICAM-1 inhibition may attenuate hypoxic pulmonary hypertension; leaves open translation to human disease.

Structured PICO

P
Population
Animal models of pulmonary hypertension (murine model under hypoxic conditions) and platelets from patients with pulmonary hypertension
I
Intervention
Pharmacological targeting of ICAM-1, platelet depletion, and platelet transfusions
C
Comparator
Control animals, thrombocytopenic mice under analogous conditions
O
Outcome
Pulmonary vascular thickening and platelet-endothelial adhesion mechanismssurrogate

Platelet-endothelial adhesion mediated by glycoprotein IIb/IIIa and ICAM-1 exacerbates pulmonary hypertension by intensifying pulmonary vascular wall thickening, highlighting a potential mechanistic therapeutic target.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6a82b4d4aa66c98ddba0cc01https://doi.org/10.1165/rcmb.2024-0438oc
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond Thrombosis: the Role of Platelets in Pulmonary Hypertension2020 · 47 citations
  2. 2The Role of Platelets in Pulmonary Hypertension: From Activation to Pulmonary Vascular Remodeling—A Review Article2026
  3. 3Platelet Activation and Fibrinopeptide Formation in Pulmonary Hypertension1993 · 22 citations
  4. 4Platelet mitofusin-1 mediates endothelial cell dysfunction in pulmonary arterial hypertension via the NLRP3 inflammasome and interleukin-1B2025
  5. 5Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension2008 · 470 citations