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July 1, 1996Clinical CardiologyOpen Access

Coagulation and fibrinolytic parameters in patients with pulmonary hypertension

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Population

Patients with primary and secondary pulmonary hypertension, and healthy human volunteers without any family…

Comparison

Measurement of coagulation and fibrinolytic… vs Healthy human volunteers (controls).

Design

Case-control

Authors

RARaúl AltmanUniversity of Buenos AiresASA. ScazziotaHospital de Clínicas "José de San Martín"JRJorge RouvierUniversity of Buenos Aires

Discussion

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Overview

Elevated PAI-1 and reduced TFPI associate with pulmonary hypertension; hypothesis-generating for prothrombotic mechanisms and antithrombotic trials.

Structured PICO

P
Population
Patients with primary and secondary pulmonary hypertension, and healthy human volunteers (controls) without any family history of thromboembolism or history of hypertensive disorders.
I
Intervention
Measurement of coagulation and fibrinolytic markers (TPA, PAI-1, TPA/PAI-1 complex, TFPI) at basal conditions and after venous stasis.
C
Comparator
Healthy human volunteers (controls).
O
Outcome
Levels of fibrinolytic and coagulation markers (PAI-1, TFPI) and euglobulin clot lysis time.surrogate

Patients with pulmonary hypertension exhibit a fibrinolytic deficit driven by elevated PAI-1 and decreased TFPI (when right atrial pressure is elevated), suggesting a prothrombotic state that may warrant antithrombotic therapy.

Cite This Study

Altman et al. (1996) studied this question.

synapsesocial.com/papers/6a80ac8c1024bacc9692c3echttps://doi.org/10.1002/clc.4960190706
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Also Consider

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  1. 1Fibrinopeptide A levels indicative of pulmonary vascular thrombosis in patients with primary pulmonary hypertension.1990 · 135 citations
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  4. 4Platelet Activation and Fibrinopeptide Formation in Pulmonary Hypertension1993 · 22 citations
  5. 5Endothelial Dysfunction Associated with Chronic Intravascular Coagulation in Secondary Pulmonary Hypertension2002 · 36 citations