Key result
Chronic intravascular coagulation, indicated by increased D-dimer, was associated with increased t-PA (p<0.0001) and vWF:Ag (p=0.001) and decreased thrombomodulin (p<0.0001) in Eisenmenger syndrome.
Population
21 patients with Eisenmenger syndrome, ages 4-52 years, categorized into stable and unstable disease.
Design
Cross-sectional
Authors
Loading...
Endothelial markers may flag coagulopathy risk in Eisenmenger syndrome; hypothesis-generating and should not yet change practice.
Observational (n=21)
p-value: p=<0.0001
In patients with Eisenmenger syndrome, endothelial dysfunction is associated with chronic intravascular coagulation and correlates with symptom severity.
Lopes et al. (2002) conducted an observational in Eisenmenger syndrome (n=21). Chronic intravascular coagulation (elevated D-dimer) vs. Normal D-dimer levels was evaluated on Endothelial markers (t-PA, vWF:Ag, thrombomodulin) (p=<0.0001). Chronic intravascular coagulation, indicated by increased D-dimer, was associated with increased t-PA (p<0.0001) and vWF:Ag (p=0.001) and decreased thrombomodulin (p<0.0001) in Eisenmenger syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: