Key result
Endothelial and small platelet-derived microparticle levels were significantly increased in patients with idiopathic, heritable, and associated pulmonary arterial hypertension compared with controls.
Why the study?
Are levels of endothelial and platelet-derived microparticles increased in different forms of pulmonary arterial hypertension compared to controls?
Population
Patients with idiopathic pulmonary arterial hypertension, heritable PAH associated with BMPR2 mutation, PAH…
Design
Case-control
Authors
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Elevated microparticle levels may mark endothelial injury in PAH; hypothesis-generating and requires prospective validation before clinical use.
Observational
Are levels of endothelial and platelet-derived microparticles increased in different forms of pulmonary arterial hypertension compared to controls?
Endothelial and small platelet-derived microparticles are significantly elevated across various forms of pulmonary arterial hypertension compared to controls, suggesting a shared pathophysiological feature.
Nadaud et al. (2012) conducted an observational in Pulmonary arterial hypertension. Pulmonary arterial hypertension (iPAH, hPAH, aPAH) vs. Controls was evaluated on Levels of endothelial-derived microparticles (EMP) and small platelet-derived microparticles (PMP). Endothelial and small platelet-derived microparticle levels were significantly increased in patients with idiopathic, heritable, and associated pulmonary arterial hypertension compared with controls.
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