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January 1, 2008Scandinavian Journal of Clinical and Laboratory Investigation

Increased level of platelet microparticles in survivors of myocardial infarction

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Why the study?

Are plasma levels of platelet microparticles increased in survivors of myocardial infarction compared to healthy controls?

Population

122 individuals, comprising 61 survivors of myocardial infarction 1-4 years post-MI and 61 age- and…

Design

Case-control

Authors

AMAnnika E. MichelsenEBEllen BrodinFBFrank Brosstad

Discussion

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Overview

Elevated PMPs may signal heightened post-MI thrombotic risk; leaves open causal role and whether levels predict events or guide therapy.

Structured PICO

Are plasma levels of platelet microparticles increased in survivors of myocardial infarction compared to healthy controls?

P
Population
122 individuals, comprising 61 survivors of myocardial infarction (MI) 1-4 years post-MI and 61 age- and sex-matched healthy controls
C
Comparator
Age-matched and sex-matched healthy controls
O
Outcome
Plasma levels of platelet microparticles (PMPs)surrogate

Survivors of myocardial infarction have significantly elevated levels of platelet microparticles, which are independently associated with thrombin generation and may contribute to increased coagulation activation.

Cite This Study

Michelsen et al. (2008) studied this question.

synapsesocial.com/papers/6a729fe331a3df82432a2f8fhttps://doi.org/10.1080/00365510701794957
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microparticles during long-term follow-up after acute myocardial infarction2017 · 46 citations
  2. 2P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial Infarction2006 · 221 citations
  3. 3Sustained elevated amounts of circulating procoagulant membrane microparticles and soluble GPV after acute myocardial infarction in diabetes mellitus2004 · 80 citations
  4. 4Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity2017 · 98 citations
  5. 5Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction2016 · 40 citations