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January 1, 2016Archives of Medical ScienceOpen Access

Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction

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Key result

Acute myocardial infarction was associated with a significantly higher number of platelet microparticles compared to unstable angina (4855 vs 2181/μl), which positively correlated with the extent of myocardial damage.

Population

41 consecutive subjects aged 30-75 years with acute coronary syndrome admitted to the intensive…

Design

Cross-sectional

Follow-up

24 hours

Authors

AHAnggoro Budi HartopoIPIra PuspitawatiPGPutrika Prastuti Ratna Gharini

Discussion

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Overview

Should not change acute coronary syndrome management; extends microparticle observations but remains hypothesis-generating.

Study Design

Type

Cross-Sectional (n=41)

Multicenter

No

Structured PICO

P
Population
41 patients aged 30 to 75 years with acute coronary syndrome (onset ≤ 48 hours) admitted to an intensive cardiovascular care unit.
O
Outcome
Number of platelet microparticles and its association with the extent of myocardial damage (determined by measuring the peak level of serial cardiac enzymes within 24 h of admission)surrogate

Main Result

Absolute Event Rate: 4855% vs 2181%

p-value: p=0.036

Increased platelet microparticles in acute myocardial infarction are associated with the extent of myocardial damage, suggesting a role in perpetuating intracoronary thrombosis.

Limitations

  • Small sample size of groups reduces the power to detect significant differences.
  • Cross-sectional design is insufficient to draw conclusions on causal relationships and proposed mechanisms.
  • Lack of coronary angiography data for assessing coronary thrombosis.
  • Excluded subjects with STEMI undergoing primary revascularisation (pPCI or thrombolysis)
  • Did not measure small-size CD42b(+)-platelet microparticles in unstable angina
  • Coronary angiography was not performed to confirm thrombus burden

Cite This Study

Hartopo et al. (2016) conducted a cross-sectional in Acute Coronary Syndrome (n=41). Acute myocardial infarction vs. Unstable angina was evaluated on Number of platelet microparticles (per μl) (p=0.036). Acute myocardial infarction was associated with a significantly higher number of platelet microparticles compared to unstable angina (4855 vs 2181/μl), which positively correlated with the extent of myocardial damage.

synapsesocial.com/papers/6a7a5cb48d250a4360f401c2https://doi.org/10.5114/aoms.2016.59926
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biomarkers of platelet activation in acute coronary syndromes2012 · 96 citations
  2. 2Endothelial Progenitor Cell Mobilization and Platelet Microparticle Release Are Influenced by Clopidogrel Plasma Levels in Stable Coronary Artery Disease2011 · 61 citations
  3. 3The Role of Platelets in Athero-Thrombotic Events2012 · 71 citations
  4. 4The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes1992 · 3,733 citations
  5. 5Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease2006 · 84 citations