Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2019BMC NephrologyOpen Access

Increased concentrations of platelet- and endothelial-derived microparticles in patients with myocardial infarction and reduced renal function- a descriptive study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Patients with CKD face high risks of recurring thrombotic events after AMI, and it was hypothesized that they have further elevated PMPs and EMPs compared to non-CKD patients despite antithrombotic treatment.

Are concentrations of platelet- and endothelial-derived microparticles elevated in AMI patients with CKD compared to those without CKD?

Population

AMI patients with CKD and non-CKD controls

Comparison

CKD stages 4-5 vs CKD stage 3 vs non-CKD group H

Design

Descriptive study

Authors

JMJosefin MörtbergUppsala UniversityKLKristina LundwallKarolinska InstitutetFMFariborz MobarrezUppsala University

Discussion

Loading...

Member takes

Overview

Elevated PMPs and EMPs in AMI patients with CKD may indicate heightened activation; hypothesis-generating for targeted therapies without practice change.

Structured PICO

Are concentrations of platelet- and endothelial-derived microparticles elevated in AMI patients with CKD compared to those without CKD?

P
Population
Patients with acute myocardial infarction (AMI) stratified by renal function (CKD stages 3, 4-5, and non-CKD group H).
C
Comparator
Non-CKD patients (group H) with AMI
O
Outcome
Concentrations of platelet-derived microparticles (PMPs) and endothelial-derived microparticles (EMPs)surrogate

AMI patients with advanced CKD have significantly higher levels of circulating platelet- and endothelial-derived microparticles, suggesting persistent platelet and endothelial activation despite concurrent antithrombotic therapy.

Cite This Study

Mörtberg et al. (2019) studied this question.

synapsesocial.com/papers/6a702cbb75498292b7098eafhttps://doi.org/10.1186/s12882-019-1261-x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques2012 · 192 citations
  2. 2Circulating Endothelial Microparticles: A Key Hallmark of Atherosclerosis Progression2016 · 79 citations
  3. 3Use of Evidence-Based Therapies in Short-Term Outcomes of ST-Segment Elevation Myocardial Infarction and Non–ST-Segment Elevation Myocardial Infarction in Patients With Chronic Kidney Disease2010 · 460 citations
  4. 4Systematic underutilisation of secondary preventive drugs in patients with acute coronary syndrome and reduced renal function2017 · 20 citations
  5. 5Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization2004 · 11,471 citations