Key result
Endothelial microparticles may identify asymptomatic CKD and renal transplant patients at higher cardiovascular risk.
Why the study?
Endothelial dysfunction begins early in kidney disease and is a risk factor for cardiovascular prognosis, but direct assessment of endothelial cells is not feasible, so circulating endothelial microparticles are studied as markers of early vascular disease in CKD.
Does the measurement of endothelial microparticles (EMPs) evaluate vascular endothelial cell damage and determine cardiovascular risk in patients with CKD and renal transplant?
Does the measurement of endothelial microparticles (EMPs) evaluate vascular endothelial cell damage and determine cardiovascular risk in patients with CKD and renal transplant?
Endothelial microparticles may serve as a reliable biomarker for early vascular disease and cardiovascular risk stratification in patients with chronic kidney disease and renal transplants.
The deterioration of endothelial structure plays a very important role in the development of vascular diseases. It is believed that endothelial dysfunction starts in the early stage of kidney disease and is a risk factor of an unfavorable cardiovascular prognosis. Because a direct assessment of biological states in endothelial cells is not applicable, the measurement of endothelial microparticles (EMPs) detached from endothelium during activation or apoptosis is thought to be a marker of early vascular disease and endothelial dysfunction in children with chronic kidney disease (CKD). Few studies have shown increased circulating EMPs and its relationship with cardiovascular risk factors in patients with CKD. MPs contain membrane proteins and cytosolic material derived from the cell from which they originate. EMPs having CD144, CD 146, CD31(+)/CD41(-), CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant.
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İsmail Dursun (2015) conducted a review in Chronic kidney disease and transplantation. Endothelial microparticles (EMPs) was evaluated. Endothelial microparticles may be used to evaluate vascular endothelial cell damage and identify asymptomatic patients at higher risk of developing cardiovascular disease in CKD and renal transplant.
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