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February 16, 2017PLoS ONEOpen Access

Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity

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Key result

STEMI patients and those developing acute heart failure during myocardial infarction had significantly higher levels of platelet- and monocyte-derived circulating microparticles compared to NSTEMI patients and those without heart failure.

Population

200 patients aged 75±4 years, evaluated 2-8 weeks after suffering an acute myocardial infarction.

Design

Cross-sectional

Follow-up

2-8 weeks post-AMI

Authors

GCGemma Chiva‐BlanchKLK LaakePMPeder L. Myhre

Discussion

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Overview

TF+ platelet- and monocyte-derived cMPs associate with STEMI and post-AMI HF; hypothesis-generating for thrombotic burden, needs prospective validation.

Study Design

Type

Cross-Sectional (n=200)

Multicenter

No

Structured PICO

P
Population
200 older adults (aged 70-82 years) evaluated 2 to 8 weeks after suffering an acute myocardial infarction to assess circulating microparticle phenotypes.
O
Outcome
Levels of Annexin V positive (AV+)-circulating microparticles (cMPs) derived from blood and vascular cells, and plasma procoagulant activity (TF-PCA)surrogate

Main Result

p-value: p=0.006

Platelet- and monocyte-derived circulating microparticles carrying tissue factor remain elevated in AMI patients and correlate with infarct severity and the development of heart failure.

Limitations

  • Observational and hypothesis-generating study design
  • Relatively low number of patients with acute heart failure and NYHA class III
  • Lack of data on microparticle shedding during the acute phase of the infarction
  • Lack of data on the specific cause of AMI in the patients

Cite This Study

Chiva‐Blanch et al. (2017) conducted a cross-sectional in Acute myocardial infarction (AMI) (n=200). ST-elevation myocardial infarction (STEMI) and acute heart failure vs. Non-ST-elevation myocardial infarction (NSTEMI) and no acute heart failure was evaluated on Levels of platelet-derived circulating microparticles (CD31+/CD42b+/AV+) (p=0.006). STEMI patients and those developing acute heart failure during myocardial infarction had significantly higher levels of platelet- and monocyte-derived circulating microparticles compared to NSTEMI patients and those without heart failure.

synapsesocial.com/papers/6a97d2dbff0077060d8be5ddhttps://doi.org/10.1371/journal.pone.0172558
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet microparticle number is associated with the extent of myocardial damage in acute myocardial infarction2016 · 40 citations
  2. 2Microparticles during long-term follow-up after acute myocardial infarction2017 · 46 citations
  3. 3Increased level of platelet microparticles in survivors of myocardial infarction2008 · 45 citations
  4. 4Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques2012 · 192 citations
  5. 5High levels of TSP1+/CD142+ platelet-derived microparticles characterise young patients with high cardiovascular risk and subclinical atherosclerosis2015 · 94 citations