Key result
Acute myocardial infarction is linked to higher platelet and platelet-monocyte tissue factor expression vs. stable controls.
Why the study?
Tissue factor on platelets and platelet monocyte aggregates may provide potential distal sites for thrombus generation, motivating investigation of their expression as participating factors in the pathogenesis of ACS.
Does tissue factor expression on platelets and platelet monocyte aggregates differ in patients with acute myocardial infarction compared to those with stable angina and healthy controls?
Case-Control (n=70)
Does tissue factor expression on platelets and platelet monocyte aggregates differ in patients with acute myocardial infarction compared to those with stable angina and healthy controls?
Elevated tissue factor expression on platelets and platelet-monocyte aggregates in acute myocardial infarction highlights a cellular mechanism linking platelet activation to hypercoagulability and thrombus formation in acute coronary syndrome.
Answers are grounded in this paper and cite their sources.
May indicate heightened thrombotic risk in AMI; hypothesis-generating for platelet tissue factor as therapeutic target in ACS.
Objective To investigate the expression of tissue factor (TF) on platelet monocyte aggregates (PMA) and platelets as a participating factor in pathogenesis of acute coronary syndrome (ACS). Background ACS is due to rupture of an arterial plaque. TF on platelets and PMA may provide potential distal sites for generation of new thrombi. In this study, the expressions of TF on PMA and platelets are investigated as participating factors in pathogenesis of ACS. Patients and methods Twenty-five patients with acute myocardial infarction, 25 patients with stable angina, and 20 clinically healthy patients as control are investigated for TF on PMA, as well as platelet-associated TF by flow cytometry analysis. Results TF on platelets and PMA were highly significant in patients with acute myocardial infarction than those with stable angina and controls. Conclusion The greater expression of TF on platelets and PMA strengthens the link between platelet activation, blood coagulation, and thrombus formation and may further contribute to the hypercoagulability associated with the disease.
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Fathy et al. (2019) conducted a case-control in Acute coronary syndrome (acute myocardial infarction and stable angina) (n=70). Acute myocardial infarction vs. Stable angina patients and clinically healthy controls was evaluated on Expression of tissue factor (TF) on platelet monocyte aggregates (PMA) and platelets measured by flow cytometry. Acute myocardial infarction patients had significantly higher tissue factor expression on platelets and platelet monocyte aggregates than stable angina patients and healthy controls.
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