Key result
Ischaemic heart disease was associated with increased monocyte tissue factor expression (>2.5%) compared to normal controls (38% in stable angina, 64% in unstable, 53% in AMI vs 0%; P=0.006).
Why the study?
Is monocyte tissue factor expression increased in patients with ischemic heart disease compared to healthy controls?
Population
71 subjects including 30 patients with acute myocardial infarction, 17 with unstable angina, 13 with chronic…
Design
Cross-sectional
Authors
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Monocyte TF expression may promote thrombosis in IHD; leaves open its value as biomarker or target.
Cross-Sectional (n=71)
Is monocyte tissue factor expression increased in patients with ischemic heart disease compared to healthy controls?
p-value: p=0.006
Monocyte tissue factor expression is significantly increased in patients with acute coronary syndromes and chronic stable angina compared to healthy controls, suggesting a mechanism for hypercoagulability in these conditions.
Leatham et al. (1995) conducted a cross-sectional in Ischaemic heart disease (n=71). Ischaemic heart disease vs. Normal control subjects was evaluated on Increased proportions of monocytes expressing tissue factor (> 2.5%) (p=0.006). Ischaemic heart disease was associated with increased monocyte tissue factor expression (>2.5%) compared to normal controls (38% in stable angina, 64% in unstable, 53% in AMI vs 0%; P=0.006).
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