Key result
Unstable angina was associated with higher levels of monocyte tissue factor expression compared to stable angina (P = .0001), with expression correlating with time from pain onset.
Population
78 patients, including 26 with unstable angina, 18 with acute myocardial infarction, and 34 with stable…
Design
Cross-sectional
Authors
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May reflect a distinct inflammatory process in unstable angina; hypothesis-generating for monocyte-targeted therapies pending prospective validation.
Observational (n=78)
p-value: p=0.0001
Time-dependent activation of systemic monocytes and increased fibrinogen occurs in unstable angina but not acute myocardial infarction, suggesting a specific inflammatory process in unstable angina.
Jude et al. (1994) conducted an observational in Unstable angina, acute myocardial infarction, or stable angina (n=78). Unstable angina vs. Stable angina and acute myocardial infarction was evaluated on Tissue factor (TF) expression in peripheral blood mononuclear cells (p=0.0001). Unstable angina was associated with higher levels of monocyte tissue factor expression compared to stable angina (P = .0001), with expression correlating with time from pain onset.