Key result
Acute coronary syndrome was associated with a significantly greater number of tissue factor-positive platelet-monocyte aggregates compared to stable angina (3-fold) or healthy controls (5-fold).
Why the study?
Does the expression of Tissue Factor in platelets and platelet-leukocyte aggregates differ in patients with acute coronary syndromes compared to those with stable angina or healthy controls?
Observational (n=80)
Does the expression of Tissue Factor in platelets and platelet-leukocyte aggregates differ in patients with acute coronary syndromes compared to those with stable angina or healthy controls?
Answers are grounded in this paper and cite their sources.
Patients with acute coronary syndromes exhibit significantly higher expression of Tissue Factor in platelets and platelet-leukocyte aggregates, which may contribute to the hypercoagulability associated with the disease.
OBJECTIVE: Activated platelets and circulating platelet-leukocyte aggregates (PLA) are significantly higher in patients with unstable angina than in those with stable angina (SA). Platelets from healthy subjects express TF on activation. The aim of this study was to investigate the expression of TF in PLA, in platelets, and in monocytes of acute coronary syndrome (ACS) patients compared to SA patients and healthy subjects (Controls). METHODS AND RESULTS: We enrolled 26 consecutive patients with ACS, 29 patients with SA, and 25 Controls. A significantly greater number of total and TF positive platelet-monocyte aggregates was found by flow cytometry in blood of ACS patients than in either SA patients (3-fold) or Controls (5-fold). ACS patients also had a significantly higher amount of TF-positive platelets than SA or Controls (>3-fold) and significantly higher thrombin generation capacity. TF mRNA expression in platelets was significantly higher in ACS patients than in SA or Controls. CONCLUSIONS: In ACS patients the greater expression of TF in platelets and PLA strengthens the link between platelet activation, blood coagulation, and thrombus formation and may further contribute to the hypercoagulability associated with the disease.
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Brambilla et al. (2008) conducted an observational in Acute Coronary Syndromes (n=80). Acute coronary syndrome vs. Stable angina and healthy controls was evaluated on Expression of tissue factor (TF) in platelet-leukocyte aggregates, platelets, and monocytes. Acute coronary syndrome was associated with a significantly greater number of tissue factor-positive platelet-monocyte aggregates compared to stable angina (3-fold) or healthy controls (5-fold).
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