Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes
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Population
76 patients, comprising 46 consecutive patients with acute coronary syndromes and 30 age- and sex-matched…
Design
Cross-sectional
Authors
Discussion
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Implication
Elevated MCP-1 and TF in ACS may reflect monocyte-driven inflammation; hypothesis-generating and should not yet change practice or guide therapy.
Structured PICO
P
Population
76 patients, comprising 46 consecutive patients with acute coronary syndromes (ACS) (mean age 64±2 years, 30 men, 16 women; 27 with unstable angina, 19 with acute myocardial infarction within 6h of onset) and 30 age- and sex-matched patients with stable exertional angina (SEA) (mean age 63±2 years, 18 men, 12 women).
C
Comparator
30 age- and sex-matched patients with stable exertional angina (SEA)
O
Outcome
Plasma levels of monocyte chemoattractant protein-1 (MCP-1) antigen and tissue factor (TF) antigen on admissionsurrogate
Circulating levels of MCP-1 and tissue factor are simultaneously elevated in acute coronary syndromes compared to stable angina, suggesting a role for monocyte-mediated inflammation and thrombogenicity in ACS pathogenesis.
Cite This Study
Nishiyama et al. (1998) studied this question.
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