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October 17, 2025Open Access

Evaluation of Metabolic Changes and Treatment Outcomes Associated with Risperidone in Paediatric Patients

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Authors

KTKarthik ThiyagarajanSri Ramachandra Institute of Higher Education and ResearchPLPaul LesselSSSindhu SelvamCardiff University

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Overview

Observational study shows significant weight gain with risperidone in children, highlighting important metabolic changes.

Key Points

  • Children showed a significant mean weight increase of 3.59 kg with risperidone treatment, indicating a notable metabolic change.
  • A correlation exists between risperidone dosage and both weight and BMI gain, reflecting the drug's dose-dependent effects.
  • Children experienced an average improvement of 34% in behavioral issues as measured by total Child Behavior Checklist scores.
  • Regular metabolic monitoring and lifestyle counseling are emphasized to mitigate the risks associated with risperidone treatment.

Cite This Study

Thiyagarajan et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dd00chttps://doi.org/10.20944/preprints202510.0995.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risperidone and Cardiometabolic Risk in Children and Adolescents2017 · 6 citations
  2. 2Weight Gain in Adolescents Treated with Risperidone and Conventional Antipsychotics Over Six Months1998 · 113 citations
  3. 3Risperidone plasma concentrations and side effects/effectiveness in children and adolescents with autism spectrum disorder2024
  4. 4Alterations of appetite-regulating hormones in risperidone treated children and adolescents - A posthoc analysis of the SPACe study2024
  5. 5Cardiometabolic Outcomes in Children and Adolescents Following Discontinuation of Long-Term Risperidone Treatment2014 · 33 citations