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April 1, 2014Journal of Child and Adolescent PsychopharmacologyOpen Access

Cardiometabolic Outcomes in Children and Adolescents Following Discontinuation of Long-Term Risperidone Treatment

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Why the study?

Does discontinuation of long-term risperidone treatment improve BMI and cardiometabolic outcomes in children and adolescents?

Population

101 medically healthy children and adolescents treated with risperidone for ≥6 months for mostly…

Comparison

Discontinuation of second-generation… vs Remaining on risperidone treatment (n=74)

Design

Cohort

Follow-up

1.5 years

Authors

CCChadi A. CalargeBaylor College of MedicineGNGinger E. NicolWashington University in St. LouisJSJanet SchlechteUniversity of Calgary

Discussion

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Overview

May support SGA discontinuation trials in overweight youth on risperidone; hypothesis-generating and requires RCTs before practice change.

Structured PICO

Does discontinuation of long-term risperidone treatment improve BMI and cardiometabolic outcomes in children and adolescents?

P
Population
101 medically healthy children and adolescents (mean age 11.7±2.6 years, 93% male) treated with risperidone for ≥6 months (mean 2.5±1.6 years) for mostly externalizing disorders.
I
Intervention
Discontinuation of second-generation antipsychotic (SGA) treatment (n=18) or switching to another SGA (n=9)
C
Comparator
Remaining on risperidone treatment (n=74)
O
Outcome
Change in age-sex specific body mass index (BMI) z score and cardiometabolic outcomes between study entry and 1.5-year follow-upsurrogate

Discontinuation of long-term risperidone in children and adolescents is associated with reversal of excessive weight gain and corresponding improvements in cardiometabolic parameters.

Cite This Study

Calarge et al. (2014) studied this question.

synapsesocial.com/papers/6a7104cea528af2d65c3dd88https://doi.org/10.1089/cap.2013.0126
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risperidone Treatment of Autistic Disorder: Longer-Term Benefits and Blinded Discontinuation After 6 Months2005 · 289 citations
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  3. 3NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, Differences From Previous Versions, and Reliability of Some Common Diagnoses2000 · 3,546 citations
  4. 4Thyroid Dysfunction During Treatment With Atypical Antipsychotics2005 · 15 citations
  5. 5Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents2009 · 89 citations