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October 17, 2025

Targeting Endothelial PERK Accelerates Lymphoid Regeneration by Enhancing DLL4-NOTCH3 Signaling at the Pre-B Niche

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Targeting endothelial PERK accelerates lymphoid regeneration, enhancing immune recovery after stem cell transplantation.
Endothelial DLL4 activates NOTCH3 in mesenchymal stroma cells, crucial for lymphoid commitment and cytokine production.
Ablation of endothelial PERK significantly boosts DLL4 expression and early HSC and B progenitor regeneration.
The PERK-DLL4 axis reveals a novel mechanism in hematopoiesis, suggesting potential therapeutic strategies for immune recovery.

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Study shows endothelial PERK activation boosts DLL4 expression and lymphoid regeneration, indicating a novel therapeutic pathway.

Zou et al. (2025) studied this question.

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