This reaction demonstrates the formation of CRf and CS bonds using diazonium salts and zinc thiolates.
A halogen atom transfer‐enabled radical fluoroalkyl‐thiolation of unactivated alkenes is developed employing fluoroalkyl iodides, TMEDA‐ligated zinc thiolates. Notably, the aryldiazonium salts are utilized as the promoter in the three‐component reaction, providing a powerful tool for simultaneous construction of CRf and CS bonds across the CC bond. Moreover, direct thiolation of fluoroalkyl iodides without alkene gives the two‐component reaction products. Mechanistic studies support that the interaction between diazonium salt and zinc thiolate plays a crucial role in the transformations.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: