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October 17, 2025Open Access

Pervasive co-regulation of alternative splicing with transcription initiation and termination.

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Authors

WWWei WuXSXiaodong SongHYHuiying Yan

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Overview

Analysis reveals significant links between transcription initiation and termination in splicing events, highlighting RBMX's role.

Key Points

  • Pervasive co-regulation between alternative splicing and TSS/PAS usage is observed across various conditions.
  • LongPASS reveals thousands of TSS/PAS-associated alternative splicing events in human cells, uncovering their widespread occurrence.
  • RBMX binding to TSS/PAS pairs is crucial for maintaining the co-regulation of splicing and transcription processes.
  • Manipulation of RNA polymerase II elongation rates directly impacts co-occurrence of TASEs and transcription sites, with aging implications.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68f199d1de32064e504dd737https://doi.org/10.21203/rs.3.rs-7727550/v1
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  1. 1Genetic regulation of nascent RNA maturation revealed by direct RNA nanopore sequencing2024
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