October 17, 2025AntibioticsOpen Access

Selective Oral Decontamination of the Esophagus to Reduce Microbial Burden in Patients Undergoing Esophagectomy for Esophageal Cancer (SODA)—First Results from a Proof-of-Principle Study

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Discussion

Proof-of-principle study shows selective oral decontamination decreases infectious complications and alters microbiome.

Selective oral decontamination reduced overall infectious complications from 55.5% to 7.7%, indicating its effectiveness.
Postoperative pneumonia incidence dropped from 33.3% to 0% with selective oral decontamination, highlighting its potential benefits.
Patients undergoing robotic-assisted esophagectomy received either decontamination or standard care to compare outcomes.
Further confirmation with larger studies is necessary as alterations in the esophageal microbiome were also observed.

Klose et al. (2025) studied this question.

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