October 17, 2025Nature CommunicationsOpen Access

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice

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Research reveals microglia regulate lipid accumulation associated with Alzheimer's disease, indicating potential targets for therapy.

Microglia regulate lipid accumulation linked to Alzheimer's disease pathology in mouse models and human brains.
Lipidomics and histological analysis showed a buildup of arachidonic acid-containing bis(monoacylglycero)phosphate due to amyloid plaques.
Microglial activity and the AD risk gene GRN are crucial for lipid regulation in Alzheimer's disease.
Notably, other lipids accumulate independently of microglia, linking to astrocyte activity and stress pathways.

Xu et al. (2025) studied this question.

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