October 18, 2025Open Access

Evidence of latent-lytic replication in EBV-positive Burkitt lymphoma from whole genome and transcriptome sequencing

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Discussion

Genomic analysis reveals mutational signatures in EBV-positive Burkitt lymphoma, suggesting links to immune evasion.

Population genomic analyses showed strain diversity in EBV, highlighting mutation and recombination in key genes.
A mutational signature associated with Burkitt lymphoma was found, enriched for specific nucleotide substitutions.
Transcription profiling indicated a mixed latent-lytic expression in Burkitt lymphoma, affecting recombination rates.
The findings open avenues for diagnostics and vaccines targeting both latent and lytic forms of EBV.

Legason et al. (2025) studied this question.

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