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October 18, 2025Egyptian Rheumatology and RehabilitationOpen Access

Immunohistochemical expression of CD138 as a marker of B cell activity in renal biopsy in lupus nephritis patients

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Authors

EAEman Karam AhmedNKNadia Salah KamelMSManal Ibrahim Salman

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Overview

Cross-sectional analysis shows CD138 expression correlates with renal disease activity in lupus nephritis, suggesting clinical utility.

Key Points

  • CD138 expression significantly correlates with renal SLEDAI scores, higher proteinuria, and elevated serum creatinine.
  • Immunohistochemical staining for CD138 was performed on biopsies from 21 lupus nephritis patients, revealing important associations.
  • The study's results highlight CD138 as a potential biomarker for assessing disease severity and activity in lupus nephritis.
  • Despite no significant correlation with biopsy class or chronicity indices, CD138 still offers supplementary information for histopathological assessments.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/68f35bfc73f0a7d050f47de7https://doi.org/10.1186/s43166-025-00357-x
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