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July 29, 2026Indian Journal of NephrologyOpen Access

Immuno-histochemical Assessment of Anti-CD45 Staining: A Predictor of Disease Activity and Short-Term Outcome in Lupus Nephritis

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Authors

NANoureen AminABAmit BariMIMuhammad Nazrul Islam

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Overview

Observational study evaluates anti-CD45 as a biomarker for disease activity in lupus nephritis, suggesting its prognostic value.

Key Points

  • This study aims to determine if anti-CD45 immunostaining predicts tubulointerstitial inflammation and correlates with clinical outcomes in lupus nephritis.
  • Enrolled 43 adults with biopsy-proven lupus nephritis at a medical university from September 2021 to August 2022.
  • Evaluated renal biopsies for leukocyte infiltration using anti-CD45 immunostaining and classified per ISN/RPS 2003 guidelines.
  • Patients were followed for 6 months to assess treatment response and clinical outcomes.
  • Anti-CD45 deposition was observed in 58.1% of interstitial compared to 41.9% of glomeruli.
  • Higher anti-CD45 deposition intensity correlated with worse SLEDAI scores (R2 = 0.253, p = 0.0077).
  • Complete remission was seen in 100% of patients with no anti-CD45 deposition but only 11.1% with severe deposition.

Cite This Study

Amin et al. (2026) studied this question.

synapsesocial.com/papers/6a69a27dc8da07d9defa5effhttps://doi.org/10.25259/ijn_841_2025
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