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October 18, 2025ChemMedChemOpen Access

Investigations on Antiproliferative Potential of Thiosemicarbazone Zn(II) Complexes: Design, Synthesis, and Density Functional Theory Studies on Structural Parameters

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Authors

SPShivendra Kumar PandeyAKAbhishek KumarSGSushil K. Gupta

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Overview

Synthesis and DFT studies reveal promising antiproliferative activity in cancer cell lines, indicating potential for therapeutic use.

Key Points

  • [Zn(MoPhHCT)2] shows significant cytotoxicity against three cancer cell lines, including HuT-78.
  • The complex demonstrates an IC50 value of approximately 4 µM against HuT-78 cells, with activities linked to glycolytic inhibition.
  • Molecular docking against BCL2 reveals a binding score of -8.34 kcal mol-1, highlighting its potential as an antiapoptotic inhibitor.
  • Western blot analysis confirms significant inhibition of BCL2 expression, suggesting a mechanism for the antiproliferative effects observed.

Cite This Study

Pandey et al. (2025) studied this question.

synapsesocial.com/papers/68f3793258f37cefb60d339ehttps://doi.org/10.1002/cmdc.202500545
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