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October 18, 2025GE Portuguese Journal of GastroenterologyOpen Access

Assessing the accuracy of the international evidence-based Kyoto guidelines for detecting malignancy in intraductal papillary mucinous neoplasms of the pancreas

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Authors

MBMadalena BorgesPRPaula RebeloFVFilipe Vilas‐Boas

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Overview

Retrospective cohort study assessing accuracy of Kyoto guidelines for malignancy in IPMNs, suggesting improvements.

Key Points

  • The Kyoto guidelines showed 100% sensitivity for detecting malignancy in IPMNs, but low specificity raises concerns.
  • With a patient sample of 106, the positive predictive value was 22.5%, indicating many false positives occur.
  • Retrospective cohort study analyzed data from patients undergoing pancreatic surgery between 2010 and 2024.
  • Future revisions of the guidelines are necessary to optimize decision-making and reduce unnecessary surgeries.

Cite This Study

Borges et al. (2025) studied this question.

synapsesocial.com/papers/68f396388da44caaba02c7a4https://doi.org/10.1159/000548886
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of four current guidelines on predicting advanced neoplasia in intraductal papillary mucinous neoplasm of the pancreas2024
  2. 2Diagnostic Performance of Surgical Indication for Branch-duct or Mixed-type Intraductal Papillary Mucinous Neoplasms of the Revised International Association of Pancreatology (IAP) 2023 Guidelines2024 · 2 citations
  3. 3Use of an Algo-Based Decision-Making Tool to Compare Real-Life Clinical Practice in a Single Tertiary Center with the Kyoto IPMN Surveillance Recommendations2026
  4. 4Danish Pancreatic Cancer Group consensus guidelines on the management of pancreatic IPMN2026
  5. 5Navigating Intraductal Papillary Mucinous Neoplasm Management through Fukuoka Consensus vs. European Evidence-Based Guidelines on Pancreatic Cystic Neoplasms—A Study on Two European Centers2024 · 2 citations