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October 16, 2025Journal of Nuclear Medicine

First-in-Human PET Imaging of MT1-MMP in a Patient with Breast and Muscle-Invasive Urothelial Bladder Cancer Using the Bicyclic Radiotracer [⁶⁸Ga]Ga-BCY25286

Ann-Christin Eder Mohamed Aymen Omrane Mohamed El Fakiri Christoph‐Ferdinand Wielenberg Cordula A. Jilg Cornelius F. Waller Michael Mix Christoph Schell Matthias Eder Philipp T. Meyer Martin T. Freitag

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Key Points

First-ever PET imaging of mt1-mmp shows promising results in bladder cancer treatment.
The imaging technique provides insight into mt1-mmp's role in tumor invasion and metastasis.
This innovative approach employs a bicyclic radiotracer for enhanced visualization of cancer cells.
Findings could potentially lead to new strategies for targeting solid tumors effectively.

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Implication

First-in-human PET imaging reveals MT1-MMP targeting in bladder cancer, suggesting implications for tumor invasion.

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Cite This Study

Eder et al. (2025) studied this question.

synapsesocial.com/papers/68f3b2fb3f213c1f8b4d34cd https://doi.org/10.2967/jnumed.125.269882

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