Emergence of carbapenem-producing enterobacteriaceae (CPE) and other multidrug-resistant gram-negative bacteria in neonates at a tertiary-level NICU in Tanzania: a point prevalence study

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Discussion

Point prevalence study showed high multidrug-resistant colonization in neonates, suggesting urgent intervention is needed.

A high prevalence of multidrug-resistant bacteria was found, with 60.7% of neonates colonized by resistant strains.
Carbapenem-producing Enterobacteriaceae were identified in 15 isolates, carrying resistance genes like blaNDM-5.
Whole-genome sequencing revealed similarities among plasmids carrying resistance genes, indicating potential transfer mechanisms.
The findings emphasize the need for enhanced surveillance and infection control measures in NICUs.

Naburi et al. (2025) studied this question.

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