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May 25, 2026Frontiers in Cellular and Infection MicrobiologyOpen Access

Molecular epidemiology and clinical profiles of carbapenem-resistant Enterobacterales in neonates from two large children’s hospitals in southwestern China

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Authors

JZJia ZhangHWH P WangHCHuimin Chang

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Overview

Randomized trial investigates risk factors and antimicrobial resistance in neonates, highlighting the prevalence of NDM-producing strains.

Key Points

  • This research aims to understand the molecular epidemiology and clinical profiles of carbapenem-resistant Enterobacterales in neonates, focusing on resistance mechanisms and associated risk factors.
  • Collected non-duplicate CRE isolates from neonates between 2018 and 2022 in two hospitals.
  • Performed antimicrobial susceptibility testing and used polymerase chain reaction to detect resistance genes.
  • Conducted multilocus sequence typing to analyze strain relatedness and logistic regression to identify risk factors.
  • 139 non-duplicate neonatal CRE isolates were identified, with high prevalence of NDM (83.5%) and significant resistance to cephalosporins and carbapenems.
  • Key risk factors included cesarean delivery (OR 3.283) and elevated white blood cell count (OR 1.049).
  • Aztreonam-avibactam showed potent in vitro activity against neonatal CRE isolates.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a13e6480e02ee3982d3156ehttps://doi.org/10.3389/fcimb.2026.1735917
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The epidemiology and clinical characteristics of carbapenem-resistant Enterobacteriaceae (CRE) isolates from children in eastern China2026
  2. 2Identification and Molecular Characterization of Carbapenem-Resistant Enterobacteriaceae in hospitalized children in Shandong, China2024
  3. 3Clinical infection and molecular characteristics of carbapenem-resistant organisms among children in China, 2016-20252026
  4. 4Carbapenem-resistant Enterobacterales infection at a South African paediatric hospital2026
  5. 5Susceptibility to novel antimicrobial agents and molecular epidemiology of carbapenem-resistant enterobacterales: a 9-year study in Central China2026 · 1 citations