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August 12, 2026BMC MicrobiologyOpen Access

Clinical infection and molecular characteristics of carbapenem-resistant organisms among children in China, 2016-2025

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Authors

HLHuiwen LiHZHaodong ZhangXYXiaoying Ye

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Overview

Randomized trial investigates carbapenem-resistant organisms in children, highlighting infection trends and risk factors.

Key Points

  • The study aims to investigate the epidemiology, clinical infection, and molecular profiles of carbapenem-resistant organisms in children in China from 2016 to 2025.
  • Retrospective analysis of 3655 non-duplicate carbapenem-resistant organism (CRO) strains isolated from Children’s Hospital of Fudan University.
  • Selection of 499 CRE strains and 315 infection cases to study characteristics.
  • Utilization of univariate comparisons and multivariable logistic regression for data analysis.
  • CRKP predominated in blood (36.9%) and urine (44.9%), while CRAB was frequently isolated from lower respiratory tract (40.0%) and cerebrospinal fluid (58.3%).
  • Prolonged hospitalization, elevated WBC and CRP levels were independent predictors of multiple CRO infections (all p < 0.05).
  • bla NDM was the major carbapenemase among pediatric CRO strains, while bla KPC-2 was higher in invasive infections.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a7c208206a85aed514b73c4https://doi.org/10.1186/s12866-026-05519-1
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  1. 1Clinical and molecular characterizations of carbapenem-resistant Klebsiella pneumoniae among children with bloodstream infections in Beijing, China2026
  2. 2The epidemiology and clinical characteristics of carbapenem-resistant Enterobacteriaceae (CRE) isolates from children in eastern China2026
  3. 3Molecular epidemiology and clinical profiles of carbapenem-resistant Enterobacterales in neonates from two large children’s hospitals in southwestern China2026
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