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June 13, 2026BMC Infectious DiseasesOpen Access

Carbapenem-resistant Enterobacterales infection at a South African paediatric hospital

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Authors

YBYemah BockarieJNJames NuttallHTHafsah Deepa Tootla

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Overview

Retrospective study describes CRE infections in children, highlighting treatment challenges and outcomes.

Key Points

  • To describe the incidence, characteristics, treatment, and outcomes of carbapenem-resistant Enterobacterales infections in children.
  • Retrospective analysis of CRE infections diagnosed from January 2016 to December 2021.
  • Data was extracted from hospital records and the National Health Laboratory Service database.
  • Clinical and microbiological characteristics of infections were analyzed.
  • Overall incidence risk was 8.4/10,000 admissions.
  • Mortality within 30 days was 33% (28/85); organ dysfunction and specific antibiotic therapies were significant risk factors.
  • Klebsiella pneumoniae was the predominant pathogen, with 73% of isolates carrying the bla OXA-48 gene.

Cite This Study

Bockarie et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f0579adhttps://doi.org/10.1186/s12879-026-13764-y
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Also Consider

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  1. 1Carbapenem-resistant Enterobacterales among hospitalized patients in Cape Town, South Africa: clinical and microbiological epidemiology2024 · 9 citations
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  3. 3Microbiological characteristics, risk factors and mortality in children with bloodstream infection of carbapenem resistance Enterobacteriaceae: a 10-year longitudinal study2024
  4. 4Molecular epidemiology and clinical profiles of carbapenem-resistant Enterobacterales in neonates from two large children’s hospitals in southwestern China2026
  5. 5Epidemiology, Molecular Characteristics, Treatment Patterns, and Outcomes of Carbapenem-Resistant Enterobacterales Infections in a Tertiary Hospital in Southern Saudi Arabia: A Retrospective Cohort Study2026