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July 15, 2026Journal of Epidemiology and Global HealthOpen Access

Epidemiology, Molecular Characteristics, Treatment Patterns, and Outcomes of Carbapenem-Resistant Enterobacterales Infections in a Tertiary Hospital in Southern Saudi Arabia: A Retrospective Cohort Study

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Authors

MAMushary AlqahtaniAAAli AlshehriMAMohammed Alshehri

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Overview

Retrospective cohort study analyzes treatment outcomes in adults with CRE infections, highlighting high mortality rates.

Key Points

  • This research aims to analyze the epidemiology, molecular characteristics, treatment patterns, and outcomes of carbapenem-resistant Enterobacterales infections.
  • Conducted a retrospective cohort study from 2021 to 2024 at a tertiary hospital.
  • Included adult patients with culture-confirmed CRE infections, collecting data on demographics, comorbidities, and clinical outcomes.
  • Performed multivariable logistic regression analysis to identify predictors of poor outcomes.
  • Included 230 patients with a mean age of 71.8 years; 54.3% died within 30 days.
  • OXA-48 was the predominant carbapenemase, found in 50.4% of the cases.
  • Ceftazidime-avibactam was associated with lower odds of poor outcomes, while colistin and tigecycline correlated with higher odds.

Cite This Study

Alqahtani et al. (2026) studied this question.

synapsesocial.com/papers/6a57236f88b21df8754801cfhttps://doi.org/10.1007/s44197-026-00608-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and molecular typing of carbapenem-resistant Enterobacterales in a secondary-care hospital in Jazan region, Saudi Arabia2026
  2. 2Progress and Epidemiology of Carbapenem Resistant Enterobacteriaceae in Saudi Arabia from 2019 to 20232024
  3. 3Epidemiology and clinical outcomes of carbapenamase-producing organism (CPO) colonization: a tertiary care center experience in Saudi Arabia2026
  4. 4Antimicrobial Resistance Trends in Carbapenem-Resistant Enterobacterales in a Saudi Healthcare Setting2026
  5. 5Detection of New Delhi metallo-β-lactamase (blaNDM) and oxacillinase (blaOXA-48) genes among carbapenem-resistant Enterobacteriaceae (CRE) in Jazan Region, Saudi Arabia2026