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August 16, 2026New Microbes and New InfectionsOpen Access

Prevalence and molecular typing of carbapenem-resistant Enterobacterales in a secondary-care hospital in Jazan region, Saudi Arabia

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Authors

HAHanan AlshafieFTFathima TarannumMAMousa Ayyashi

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Overview

Cross-sectional study demonstrates a 10% CRE prevalence driven by NDM and OXA-48 genes in hospitalized patients, highlighting the need for targeted infection control and device surveillance.

Key Points

  • To evaluate the prevalence of carbapenem-resistant Enterobacterales, profile their carbapenemase resistance genes, and identify associated clinical risk factors among hospitalized patients.
  • Analyzed consecutive clinical Enterobacterales isolates (N=260) collected from hospitalized patients in a secondary-care center between June 2023 and April 2024.
  • Extracted demographic and clinical variables from electronic medical records and evaluated risk factor associations using R and IBM SPSS Statistics.
  • Of 260 Enterobacterales isolates, 26 (10%) were carbapenem-resistant, predominantly consisting of Klebsiella pneumoniae (81%), Enterobacter cloacae complex (11%), Escherichia coli (4%), and Klebsiella oxytoca (4%).
  • The most common resistance mechanism was the NDM carbapenemase gene (58%), followed by co-occurring OXA-48 and NDM (23%), and OXA-48 alone (19%).
  • Carbapenem-resistant Enterobacterales isolation was significantly associated with intensive care unit admission, central line placement, and urinary catheter use.

Cite This Study

Alshafie et al. (2026) studied this question.

synapsesocial.com/papers/6a81794cf2fb91fc834ac79ahttps://doi.org/10.1016/j.nmni.2026.101825
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